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Sponsored2026 · Telehealth GLP-1
The 5 best online GLP-1 programs, compared.
We lined up 5 telehealth GLP-1 programs on monthly cost, medication choice, delivery speed, refunds and real Trustpilot ratings. The short version: DirectMeds gives most people the best all-round deal, and BrightMeds is the cheapest where it’s available.
Advertising disclosure: This is a paid advertorial, not independent journalism. We receive compensation from the providers featured. Scores are editorial opinion, not clinical results. Not medical advice. Full disclaimer.
FDA notice: Some featured programs offer compounded semaglutide and tirzepatide, including injections and under-the-tongue (sublingual) drops. Compounded drugs are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality. No sublingual GLP-1 product is FDA-approved. Prescription required.
There are now dozens of online clinics selling GLP-1 weight-loss medication. Most look the same from the outside: a short quiz, a licensed provider, a package in the mail. The real differences hide in the details: what the monthly price actually includes, which medications you can get, how fast it ships and what happens if you aren’t approved.
So we lined up five popular programs side by side, using each provider’s own published prices and policies plus what thousands of patients say about them on Trustpilot. A couple came out clearly ahead. Others are a great fit for one specific need.
The short version: DirectMeds gives most people the best overall deal, with one all-in monthly price, a needle-free option and the biggest base of patient reviews on this list. If price is all that matters, BrightMeds starts at $99 a month, but it isn’t available in every state.
The full rankings are below, followed by a closer look at why DirectMeds is our top pick.
Important: compounded medications are not FDA-approved
Several programs below prescribe compounded semaglutide or tirzepatide, including injections and under-the-tongue (sublingual) drops. Compounded drugs are prepared by pharmacies and are not FDA-approved; the FDA does not verify their safety, effectiveness or quality before they are sold. No sublingual GLP-1 formulation is FDA-approved. Brand-name Wegovy® and Zepbound® are FDA-approved. All GLP-1 medications require a prescription from a licensed provider, who decides whether treatment is right for you.
Paid advertorial. Prices from provider sites, Oct 15, 2026; may be promotional. Prescription required. Compounded drugs are not FDA-approved.
How we evaluated the top 5
Real monthly costStarting price, refill price and any membership or consult fees
Medication choiceSemaglutide, tirzepatide, brand-name, tablets or drops
SpeedProvider review time and shipping to your door
Refunds & termsRefund if not approved, membership, cancel anytime
Patient ratingsTrustpilot score and how many people reviewed
Based on each provider’s published prices and policies, checked Oct 15, 2026. We don’t test medications.
What you’ll pay per month
Lowest advertised starting price for each program. Most prices are all-in, covering the clinician review, medication and shipping. Some are first-month or multi-month promos, so check the details before you start.
Out of the five programs we compared, DirectMeds came out ahead on the things that matter most once you’re a few months in: what you pay, what you get, and how easy it is to start.
One price that doesn’t jump
DirectMeds charges $147 a month for its under-the-tongue semaglutide drops, and that price includes the clinician review, the medication and shipping. There’s no separate membership fee stacked on top. MEDVi’s $149 first month is similar, but its refills rise to $299 a month after that. TrimRx starts at $179 for semaglutide and $259 for tirzepatide. Over several months, a flat all-in price is simply easier to plan around.
Every program here starts with an online consultation reviewed by a licensed provider.
A needle-free option
Not everyone is comfortable with weekly injections. DirectMeds is the only program on this list that offers under-the-tongue drops, alongside injections at $297 a month. (MEDVi is the other option if you’d rather avoid needles: it offers tablets.)
FDA notice: DirectMeds’ drops and injections are compounded. Compounded medications are not FDA-approved, and no sublingual (under-the-tongue) GLP-1 product has been approved by the FDA. The FDA has not reviewed their safety, effectiveness or quality. Talk to a licensed provider about the risks.
Both leading ingredients
You can be prescribed semaglutide or tirzepatide, the active ingredients behind the best-known GLP-1 brands. A licensed provider decides which one, and which dose, fits you. DirectMeds’ medications are compounded, which keeps costs down but means they aren’t FDA-approved. If you specifically want brand-name Wegovy® or Zepbound®, MEDVi is the better fit.
“If you want one program that balances price, choice and convenience, DirectMeds is where we’d start.”
A low-risk start
If a provider reviews your health information and decides GLP-1 treatment isn’t right for you, DirectMeds advertises a full refund. Approved orders ship in 1–2 business days.
Patients back it up
DirectMeds holds a 4.6 rating on Trustpilot from more than 16,500 reviews, the largest review base of the five programs here. A rating isn’t everything, but a high score across that many reviews is a good sign the experience holds up at scale.
The bottom line
For most people, DirectMeds offers the best balance of price, choice and convenience. If you need the absolute lowest price and live in a state BrightMeds serves, check BrightMeds first.
By the Weightlisting Editorial Team · Reviewed Oct 15, 2026
We compare telehealth GLP-1 programs using each provider’s published prices and policies plus public Trustpilot ratings. We don’t sell medication or give medical advice, and some providers listed pay us. About us · Disclosure
FAQ
Who qualifies?
A licensed clinician decides. Typically adults with a BMI of 30+, or 27+ with a weight-related condition.
Do I need insurance?
No. All five are self-pay, and some (such as MEDVi) accept HSA/FSA cards.
Compounded vs. brand-name?
Compounded versions, including sublingual drops, cost less but are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality. Wegovy® and Zepbound® are FDA-approved.
How fast will it arrive?
After approval, InstaRx advertises delivery in as little as 2 days and DirectMeds ships in 1–2 business days. Others vary by state.
What if I’m not approved?
DirectMeds and BrightMeds advertise a full refund if a provider doesn’t prescribe. Check each provider’s terms before paying.
Side effects?
Most common: nausea, diarrhea and constipation. Rare: pancreatitis and gallbladder issues. Ask your prescriber.
GLP-1 medications are prescription-only and not right for everyone. Do not use if you or a family member had medullary thyroid carcinoma, or if you have MEN 2. Individual results vary. Not medical advice. Wegovy® is a trademark of Novo Nordisk; Zepbound® of Eli Lilly. Full disclaimer
This page is a paid advertorial brought to you by weightlisting.com. It is intended for promotional purposes only and should not be considered independent journalism, editorial content, or consumer advice. The content has been created or curated by the advertiser and may include affiliate links. We may receive compensation if you choose to purchase a featured product or service via the links provided. Please refer to our Advertising Disclaimer and Privacy Policy for more information.
Sponsored · Top Pick: DirectMedsFrom $147/mo · compounded, not FDA-approvedCheck Eligibility
directmeds.com
